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From worstpreviews, New Line Cinema is making some big changes to "My Sister's Keeper" by replacing Elle Fanning with Abigail Breslin and Dakota Fanning with Sofia Vassilieva. Sources said Dakota Fanning balked at a request that she shave her head for the role and both sisters withdrew abruptly.

Breslin, who was Oscar-nominated for "Little Miss Sunshine," will take over the role of a young girl who sues for emancipation from parents who conceived her as a genetic match so she could prolong the life of her ailing older sister. Vassilieva ("Medium") would play the older sister.

Cameron Diaz plays the mother of the girls, a tough lawyer who takes her own case in court. Alec Baldwin plays the attorney who represents the child. Joan Cusack will also star in the drama, a Jeremy Leven-scripted adaptation of the Jodi Picoult novel.

Production is still on track for March, with Nick Cassavetes (Alpha Dog, The Notebook) directing.